1 〔反応を示す〕respond ((to))，answer; 〔報いる〕reward
The doctor came at once in answer [response] to my telephone call.
You must reward him for his services.
He couldn't live up to his parents' expectations.
2 〔体に強く感じる〕((物事を主語にして)) tell ((on))，affect; ((人を主語にして)) really feel
This cold weather 「is very hard [really tells] on me.／I really feel this cold weather.
The death of his son has 「definitely told on him [really affected him].
His sermon came home to me.
Her biting sarcasm seems to have really hit him hard.